Shikimate Pathway The shikimate pathway is a metabolic pathway that synthesizes aromatic amino acids, such as phenylalanine, tyrosine, and tryptophan, and a variety of other aromatic compounds, such as quinones, flavonoids, and lignin. Stages Stage 1: The synthesis of shikimate from phosphoenolpyruvate (PEP) and erythrose 4-phosphate. This step is catalyzed by the enzyme 3-dehydroquinate synthase (DHS). DHS condenses PEP and erythrose 4-phosphate to form 3-dehydroquinate. 3-dehydroquinate is then reduced to shikimate by the enzyme shikimate dehydrogenase (SDH). Stage 2: The conversion of shikimate to chorismate. The key enzymes in this stage are shikimate kinase (SK), 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS), chorismate synthase (CS), and chorismate mutase (CM). Stage 3: The conversion of chorismate to aromatic amino acids and other aromatic compounds. Chorismate can be converted to a variety of aromatic amino acids and other aromatic compounds, including phenylalanine,
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